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| Знайдено в інших БД: | Реферативна база даних (5) |
Список видань за алфавітом назв: Авторський покажчик Покажчик назв публікацій  |
Пошуковий запит: (<.>A=Dumanskiy Y$<.>) | |||
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Загальна кількість знайдених документів : 3 Представлено документи з 1 до 3 |
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| 1. | 
Dumanskiy Y. V. Markers of epithelial-mesenchymal transition in renal cell carcinoma [Електронний ресурс] / Y. V. Dumanskiy, A. G. Kudriashov, I. V. Vasilenko, R. B. Kondratyuk, Y. K. Gulkov, R. S. Chystiakov // Experimental oncology. - 2013. - Vol. 35, № 4. - С. 325-327. - Режим доступу: http://nbuv.gov.ua/UJRN/EOL_2013_35_4_18 Aim - to study the influence of markers of epithelial-mesenchymal transition (EMT) on a renal cell carcinoma (RCC) prognosis. The surgical material of 47 RCC patients who underwent nephrectomy was studied. RCC patients were distributed in two groups: a short-term survival group (3 - 6 months) and a long-term survival group (17 - 24 months). EMT markers expression was assessed by immunohistochemical methods. It was determined that the rate of spindle-cell EMT was 96,4 % in a short-term survival group and 42,1 % in a long-term survival group. High rate Furhman's nuclear atypia, i.e. degree 3 - 4 occurred in 100 % of cases in a short-term survival group versus 68,4 % in a longterm survival group. Conclusion: the rate of spindle-cell EMT in RCC may serve a more sensible prognostic factor than the degree of Furhman's nuclear atypia. | ||
| 2. |
Stashkevych M. The influence of 5-fluorouracil on activity of thymidine phosphorylase in gastric adenocarcinoma and normal adjacent tissue [Електронний ресурс] / M. Stashkevych, E. Khomutov, Y. Dumanskiy, A. Matviyenko, I. Zinkovych // Experimental oncology. - 2014. - Vol. 36, № 4. - С. 267-270. - Режим доступу: http://nbuv.gov.ua/UJRN/EOL_2014_36_4_12 The aim of the present study was to evaluate the change of thymidine phosphorylase (TP) activity in gastric adenocarcinoma and adjacent tissue upon the intraarterial administration of 5-fluorouracil (5-FU). The specimens of tumor and adjacent tissue were obtained by surgical operation on 36 patients (20 men and 16 women aged from 38 to 82 years) with gastric adenocarcinoma (stages II - IV). 5-FU was administered in the bolus dose to the gastroepiploic artery 2 - 60 min before the tumor resection. The concentration of 5-FU and activity of TP in both tissues were determined by high performance liquid chromatography method. The concentration of 5-FU was decreased in a tune-dependent manner in both tissues, though the interpatient variability of this value was much less in tumor tissue. The activity of TP was decreased with the course of the time after 5-FU administration in tumor and normal adjacent tissue. There were statistically significant differences in the TP activity in both tissues between 2 - 20 min and 40 - 60 min after 5-FU injection (p << 0,05). Conclusion: 5-FU administration results in the decrease of TP activity in tumor and normal adjacent tissues that might have importance for chemotherapy with fluoropyrimidines. | ||
| 3. |
Dumanskiy Yu. V. Endothelial dysfunction of vessels at lung cancer [Електронний ресурс] / Yu. V. Dumanskiy, O. Yu. Stoliarova, O. V. Syniachenko, E. D. Iegudina // Experimental oncology. - 2015. - Vol. 37, № 4. - С. 277-280. - Режим доступу: http://nbuv.gov.ua/UJRN/EOL_2015_37_4_9 Aim - to evaluate changes in indicators of endothelial function and their relationship with morphological forms of disease, stage of pathological process and tumor markers, by analysis the peripheral blood of lung cancer (LC) patients. 38 LC patients without metastases (mean age - 57 years) prior chemo- and radiotherapy were included in the study. The duration of the disease manifestation was 18 months. 21 % of patients had small cell LC, and the rest - non-sinall cell LC. The ratio of patients with stages IA, IB, IIA, IIB, IIIA and IIIB LC was 1 : 3 : 3 : 4 : 4 : 4. The enzyme immunoassay, spectrophotometry, and statistical data analysis were used. Endothelial dysfunction of vessels was characterized by increased blood levels of vascular endothelial growth factor (VEGF), endothelin-1 (ET1), homocysteine (HCys), cyclic guanosine monophosphate (cGMP), P-selectin (PSel) and nitrites (N02) and simultaneously by decreased values of prostacyclin (PgI2). Those were observed in 100; 90; 76; 71; 50; 53 and 79 % of LC cases, respectively. Disturbances of vascular endothelial function were associated with patient's age, disease duration, and morphological form and LC stage. Such changes were observed in women with higher prevalence. The studied indices correlated with tumor markers, namely transforming growth factor beta (TGFpl), fibronectin and osteopontin. Conclusion: indices of vascular endothelial dysfunction in LC can be of diagnostic and prognostic value. | ||
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